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Istradefylline forty mg/day amplified peak amounts and AUC of CYP3A4 substrates in medical trials. This outcome was not noticed with istradefylline twenty mg/working day. Think about dose reduction of sensitive CYP3A4 substrates.crizotinib raises amounts of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. D